Colts quarterback Andrew Luck leads the MVP race after winning the AFC South with a 23-14 win over the New England Patriots on Sunday night.
Luck finished with 331 yards and three touchdowns on 26-of-36 passing for a total of 438 yards and four touchdowns, including a 41-yard touchdown run with 3:22 remaining in the third quarter.
New England, which lost to Indianapolis in Week 3, was unable to make the playoffs for the first time since the 1990 season.
Luck, who had three interceptions, led the Colts to the AFC title game after throwing four touchdown passes.
Luck was the second-leading rusher with 632 yards.
The Colts (10-5) are in second place in the AFC East, one game ahead of the Jacksonville Jaguars (8-6) who also are in the division title race.
Indianapolis lost quarterback Peyton Manning to the Denver Broncos in free agency, but Luck was able to take over in Week 1, leading the Colts in passing and passing efficiency, and the NFL with a passer rating of 100.2.
Luck is the first Colts quarterback to win the MVP award since Tom Brady in 2006.